Adult Reconstruction - Periprosthetic Joint Infection
A 68-year-old man with type 2 diabetes (HbA1c 8.9 per cent) had an uncomplicated total knee arthroplasty 18 days ago. He presents with a three-day history of increasing pain, a swollen warm knee, a temperature of 38.2 degrees, and persistent serous discharge from the distal third of the wound. CRP is 145 and white cell count 13.2. Radiographs show well-fixed, well-aligned components. He is walking with a frame and is systemically well otherwise. The panel asks: how do you investigate and treat this, and how would your approach differ if he presented at three years instead?
What the panel is testing: Systematic diagnosis of periprosthetic joint infection against accepted criteria, and the judgement behind debridement with implant retention versus staged revision. It also probes host optimisation and honest counselling about outcomes.
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Knowledge: This is an acute postoperative periprosthetic joint infection until proven otherwise, and persistent wound drainage beyond five to seven days is itself a marker of infection, not a benign finding. I would use a formal definition such as the European Bone and Joint Infection Society or the 2018 International Consensus Meeting criteria rather than an impression, combining serum markers, synovial fluid analysis, microbiology and histology.
Management: I would admit him, withhold antibiotics until samples are taken, and perform an aseptic knee aspiration sending fluid for cell count and differential, Gram stain, culture and, where available, alpha-defensin. I would take blood cultures, check inflammatory markers serially, review the operative and microbiology record, and involve infectious diseases early.
Ethics and communication: Infection after arthroplasty is emotionally devastating for patients, and my duty is to be honest early rather than to minimise it as a superficial wound problem.
Likely panel follow-up questions
- Give me the diagnostic criteria you use for periprosthetic joint infection and the synovial thresholds at three weeks versus three years.
- Justify debridement with implant retention here, and list the factors that would make you abandon it in favour of two-stage revision.
- What is the role of rifampicin, and when must you not use it?
Pitfalls in this case
- Calling persistent wound drainage at 18 days a superficial problem and treating with oral antibiotics
- Starting empirical antibiotics before aspiration and tissue sampling, destroying culture yield
- Performing an arthroscopic washout or a debridement without exchanging the polyethylene insert
Reference: EBJIS Definition of Periprosthetic Joint Infection, Bone and Joint Journal, 2021; and Proceedings of the International Consensus Meeting on Musculoskeletal Infection, 2018