Oral Medicine
A 58-year-old man, a smoker of 30 years who drinks alcohol daily, is referred with a painless ulcer on the lateral border of his tongue. It is 18 mm across, has raised rolled margins and a firm base, and has been present for five weeks. He tried a steroid mouthwash from his pharmacy with no change. There is a firm, non-tender level II lymph node on the same side. What is your approach?
What the panel is testing: Whether you recognise suspected oral squamous cell carcinoma, act without delay on the urgent pathway, and communicate a possible cancer diagnosis well.
Show the answer outline
Knowledge: A persistent ulcer of more than three weeks on the lateral or ventral tongue in a smoker and drinker with a firm node is oral squamous cell carcinoma until proven otherwise. The lateral tongue is the commonest oral site. Important differentials are a traumatic ulcer, aphthous ulcer, a deep fungal or tuberculous ulcer, syphilis and lymphoma, but none of them removes the need for biopsy. Clinical staging uses tumour size and depth of invasion, node status and metastasis, with the 8th edition AJCC adding depth of invasion. A non-healing ulcer that has not responded to steroid after 2 to 3 weeks should not be treated further empirically. Potentially malignant disorders such as leukoplakia may be seen nearby and I would examine the whole mouth.
Management: I would take a full history and examine the head and neck, noting the site, size, induration, fixation and nodes in all levels. I would arrange an incisional biopsy from the edge including adjacent normal tissue, ideally at the first visit or through the urgent route. I would refer at once to the head and neck cancer multidisciplinary team, with imaging requested by them, such as MRI or CT and ultrasound of the neck. I would not wait for a laboratory result to refer, and I would not start treatment myself. I would also address tobacco and alcohol cessation, dental assessment before radiotherapy, nutrition and swallowing, and arrange a clear follow-up so that he is not lost.
Ethics and communication: I would tell him honestly that this ulcer may be cancer, that a biopsy is needed to know, and that speed matters, in simple language and with an interpreter if needed, and with a family member present if he agrees. I would record the discussion and obtain consent for the biopsy under Cabinet Resolution No. 40 of 2019. Delay in referral may expose me to liability under the Medical Liability Decree-Law, Federal Decree-Law No. 4 of 2016, so I would document the date of referral and follow up that the appointment took place. I would respect his autonomy if he declines but would explain the risk clearly.
Likely panel follow-up questions
- The biopsy shows moderate dysplasia only. Do you accept this?
- He is anxious and asks if he will lose his tongue. What do you say?
- What would change your management if the ulcer were 1 week old and clearly under a sharp tooth?
- Which dental work would you want completed before radiotherapy?
Pitfalls in this case
- Prescribing more antifungal or steroid and reviewing in a month
- Not feeling or recording the cervical nodes
- Doing a biopsy of necrotic centre only, or no biopsy
- Failing to arrange follow-up and tracking of the referral
Reference: WHO Classification of Head and Neck Tumours (5th ed, 2022); Scully C, Oral and Maxillofacial Medicine: The Basis of Diagnosis and Treatment (3rd ed, 2013)